Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes |
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| Authors: | Jean-Sébastien Rougier Olivier Muller Stefan Berger Gabriel Centeno Günther Schütz Dmitri Firsov Hugues Abriel |
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| Institution: | (1) Department of Pharmacology and Toxicology, University of Lausanne, Bugnon, 27, 1005 Lausanne, Switzerland;(2) Service of Cardiology, CHUV, Lausanne, Switzerland;(3) German Cancer Research Center, Division Molecular Biology of the Cell I, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;(4) Department of Pharmacology and Toxicology, and Service of Cardiology, University of Lausanne, Bugnon, 27, 1005 Lausanne, Switzerland |
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| Abstract: | Despite the fact that mineralocorticoid receptor (MR) antagonist drugs such as spironolactone and eplerenone reduce the mortality
in heart failure patients, there is, thus far, no unambiguous demonstration of a functional role of MR in cardiac cells. The
aim of this work was to investigate the activation pathway(s) mediating corticosteroid-induced up-regulation of cardiac calcium
current (I
Ca). In this study, using neonatal cardiomyocytes from MR or glucocorticoid receptor (GR) knockout (KO) mice, we show that MR
is essential for corticosteroid-induced up-regulation of I
Ca. This study provides the first direct and unequivocal evidence for MR function in the heart. |
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| Keywords: | Corticosteroids Nuclear receptors Aldosterone Calcium current |
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