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| 地龙提取物的抗凝血作用 | |
| 引用本文： | 何红,车庆明,孙启时.地龙提取物的抗凝血作用[J].中草药,2007,38(5):733-735. |
| 作者姓名： | 何红 车庆明 孙启时 |
| 作者单位： | 1. 北京大学药学院,北京,100083;沈阳药科大学中药学院,辽宁,沈阳,110016 2. 北京大学药学院,北京,100083 3. 沈阳药科大学中药学院,辽宁,沈阳,110016 |
| 摘 要： | 目的研究地龙提取物的抗凝血作用。方法观察地龙提取物对小鼠凝血、出血时间和家兔离体血浆复钙时间的影响,测定提取物中游离氨基酸的量。结果地龙提取物能延长小鼠凝血、出血时间和家兔离体血浆复钙时间。游离氨基酸测定结果表明,提取物中含有丰富的氨基酸。结论地龙提取物所含的游离氨基酸可能是其抗凝血作用的有效成分。 |
| 关 键 词： | 地龙 抗凝血作用 氨基酸 |
| 文章编号： | 0253-2670（2007）05-0733-03 |
| 收稿时间： | 2006/8/22 0:00:00 |
| 修稿时间： | 2006-08-22 |
Anticoagulant effects of Pheretima extracts |
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| HE Hong,CHE Qing-ming and SUN Qi-shi.Anticoagulant effects of Pheretima extracts[J].Chinese Traditional and Herbal Drugs,2007,38(5):733-735. | |
| Authors: | HE Hong CHE Qing-ming and SUN Qi-shi |
| Institution: | 1. College of Pharmaceutical Science, Beijing University, Beijing 100083, China ; 2. College of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China |
| Abstract: | Objective To study the anticoagulant effects of Pheretima extracts and analyze the effective constituents. Methods Antithrombotic effects of Pheretima extracts were observed by determining the coagulation time, bleeding time of mice and the recalcification time of rabbit plasma in vitro, meanwhile the content of free amino acid in the extracts were determined. Results Pheretima extracts could prolong the coagulation time, bleeding time of mice, and the recalcification time of rabbit plasma in vitro. The content of free amino acid was rich in Pheretima extracts. Conclusion Free amino acid in Pheretima extracts may be the main anticoagulant effective constituents. |
| Keywords: | Pheretima anticoagulant effects amino acid |
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