Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study |
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Authors: | Massana Guillem Serra-Grabulosa Josep Maria Salgado-Pineda Pilar Gastó Cristòbal Junqué Carme Massana Joan Mercader José María |
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Affiliation: | Institut Clínic de Psiquiatria i Psicologia, Corporació Sanitària Clínic, I.D.I.B.A.S., Barcelona, Catalonia, Spain. trocosmos@yahoo.es |
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Abstract: | OBJECTIVE: The authors examined possible cerebral gray matter abnormalities in patients with panic disorder. METHOD: Gray matter concentration in 18 panic disorder outpatients and 18 healthy subjects was compared by using a voxel-based morphometry approach. RESULTS: Gray matter density of the left parahippocampal gyrus was significantly lower in patients with panic disorder compared with healthy subjects. CONCLUSIONS: This result provides further support for the involvement of the parahippocampal area in the pathophysiology of panic disorder. |
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