异甘草酸镁治疗中毒性肝炎疗效观察

目的 观察异甘草酸镁治疗中毒性肝炎的疗效.方法 160例临床确诊为中毒性肝炎住院患者完全随机分为观察组和对照组,各80例.2组均常规给予维生素及氨基酸类等药物治疗,观察组在此基础上给予异甘草酸镁注射液150 mg静脉滴注,对照组在此基础上给予还原型谷胱甘肽注射液1.8g静脉滴注,1次/d,疗程均为4周.观察2组患者的症状改善情况、肝功能及不良反应.1个月后治疗无效者换用其他治疗.结果 观察组乏力好转率95.0％(76例),好转时间10(5～15)d;对照组分别为86.2％(69例)、18(14 ～22)d.观察组消化道症状好转率93.8％(75例),好转时间12(8～16)d；对照组分别为83.8％(67例)、21(16 ～26)d.观察组ALT好转率97.5％(78例),好转时间15(10～20)d;对照组分别为88.8％(71例)、25(20 ～30)d.观察组血清总胆红素好转率96.2％(77例),好转时间14(9 ～ 19)d;对照组分别为87.5％(70例)、23(18 ～28)d.观察组乏力、消化道症状、ALT、总胆红素好转率和好转时间均明显优于对照组,差异均有统计学意义(均P ＜0.05).观察组显效58例(72.5％),有效18例(22.5％),总有效率95.0％(76例),对照组显效50例(62.5％),有效19例(23.8％),总有效率86.3％(69例).观察组总有效率明显高于对照组,差异有统计学意义(P＜0.05).2组均无明显不良反应.结论 异甘草酸镁治疗中毒性肝炎的疗效优于还原型谷胱甘肽.

Magnesium isoglycyrrhizinate in the treatment of toxic hepatitis

Objective To observe magnesium isoglycyrrhizinate （MgIG） in the treatment of toxic hepatitis. Methods One hundred and sixty toxic hepatitis patients were randomly divided into treatment group （80 cases ） and control group （80 cases）. Both groups had a vitamin, amino acids and other drugs. The observation group was given MgIG injection of 150 mg intravenous infusion on the basis of routine treatment; the control group was given 1.8 g intravenous infusion of glutathione injection. Both groups were treated for 4 weeks. Results The improvement rate of fatigue, gastrointestinal symptoms, alanine transarninase, total bilirubin in observation group were significantly better than those in the control group （ P 〈 0.05 ）. The total effective rate of observation group was higher than that in control group 95.0% （76/80） vs 86.3% （69/80）, P 〈 0.05 ]. Conclusion MgIG may be more effective than glutathione for toxic hepatitis.