药浴疗法对慢性疲劳综合征的干预研究

目的 观察中医疏肝健脾药浴疗法对肝郁脾虚型慢性疲劳综合征(CFS)的干预效果.方法 228例肝郁脾虚型慢性疲劳综合征患者依据随机表,受试者按2:1:1比例分为3组,研究中缺失16例,最终212例患者符合要求,药浴组(106例)、逍遥丸组(56例)、对照组(50例).药浴组采用疏肝健脾中药配方进行药浴干预,4周为1个疗程；对照组给予安慰剂(食品色素柠檬黄)对照,隔日1次,4周为1个疗程；逍遥丸组口服逍遥丸8粒/次,2次/d.采用中医证候量表、匹兹堡睡眠质量指数、简易症状量表等作为观察指标,综合评价药浴疗法对CFS的干预效果.实验数据以(x)±s表示,组间比较用方差分析,方差不齐时采用K-W 和LSD秩和检验.均数比较用t检验.结果 干预后药浴组患者中医症候主要阳性症状评分明显优于干预前.3组中医证候疗效为药浴组显效6例(5.7％)、有效65例(61.3％)、无效35例(33.0％)；对照组分别为0(0)、7例(14.0％)、43例(86.0％)；逍遥丸组分别为8例(14.3％)、35例(62.5％)、13例(23.2％).药浴组和逍遥丸组有效率明显高于对照组有效率,差异有统计学意义(x2=38.39、42.54,均P＜0.01),药浴组与逍遥丸组差异无统计学意义.采用减分率的计算方法对简易症状量表干预后疗效进行评定,药浴组显效6例(5.7％)、有效83例(78.3％)、无效17例(16.0％)；对照组分别为0(0)、4例(8.0％)、46例(92.0％)；逍遥丸组分别为2例(3.6％)、44例(78.6％)、10例(17.8％).药浴组和逍遥丸组总有效率明显高于对照组,差异有统计学意义(x2=43.10、45.98,均P＜0.01),药浴组与逍遥丸组差异无统计学意义.结论 疏肝健脾中医药浴对缓解CFS有良好效果,可作为CFS的有效治疗方法之一.

Effects of traditional Chinese medical herbs bath in the treatment of chronic fatigue syndrome

Objective To observe the therapy effect of Traditional Chinese Medicine （TCM） bath in patients with Chronic Fatigue Syndrome（CFS）. Methods A total of 212 patients with CFS characterized by stagnation of liver-Qi with deficiency of the spleen were randomly assigned into TCM group（ n = 106）, control group（ n = 50 ） and Xiaoyaowan group（ n = 54 ）. Patients in the TCM group were treated with Chinese herbal bath ;control group were treated with lemon yellow, once every other day for 4 weeks and Xiaoyaowan group were taken orally with dosage of eight pills every time, twice a day. The effects of TCM bath were evaluated by using TCM Symptom Table, Pittsburgh Sleep Quality Index questionnaire （PSQI） and simple symptom scale. Results The main positive symptoms＇ scores of TCM symptom table were lower after TCM bath treatment, as compared with those in control group （ P 〈 0. 05）. The ratio of sickness curative effect in TCM group and Xiaoyaowan group was higher than that in control group （P 〈 0. 01）. Conclusions TCM herbs bath may attenuate the syndrome of CFS. It is suggested that TCM herbs bath is a new approach to treat CFS.