兰索拉唑联合莫沙必利治疗非糜烂性胃食管反流病的疗效观察

目的 观察兰索拉唑治疗非糜烂性胃食管反流病(NERD)的疗效.方法 将64例NERD患者完全随机分为观察组和对照组.观察组32例,予兰索拉唑30 mg,早餐前1次；莫沙比利5 mg,早、中、晚餐前各1次；对照组32例,予兰索拉唑30 mg,早餐前1次.治疗前及治疗8周时进行胃食管反流病量表(GerdQ)评分,并于治疗8周后进行疗效评定.结果 观察组显效20例,有效7例,总有效率为84.4％ (27/32)；对照组显效15例,有效5例,总有效率为62.5％ (20/32)；2组总有效率比较差异具有统计学意义(P＜0.05).治疗8周后2组GerdQ评分均较治疗前下降观察组:(7.0±2.0)分比(9.8±2.6)分；对照组:(8.2±2.0)分比(10.3±2.1)分；均P＜0.05],且治疗8周后观察组GerdQ评分低于对照组(P＜0.05).结论 兰索拉唑联合莫沙比利治疗NERD疗效优于单用同剂量兰索拉唑.

Effect of lansoprazole and mosapride in the treatment of non-erosive gastroesophageal reflux disease

Objective To explore the clinical efficacy of lansoprazole combined with mosapride in the treatment of non-erosive gastroesophageal reflux disease （NERD）. Methods All 64 cases of NERD were randomly divided into two groups. The observation group was treated with lansoprazole combinedwith mosapride for 8 weeks. The control group was given lansoprazole for 8 weeks. Clinical efficacy and gastroesophageal reflux disease questionnaire （GerdQ） score were compared before and after the treatment. Results In the observation group, significant efficacy was found in 20 cases, efficacy in 7 cases, and inefficacy in 5cases and the total effective rate was 84.4% （27/32）. In the control group, significant efficacy was found in 15 cases, efficacy in 5 cases, and inefficacy in 12 cases, and the total effective rate was 62.5% （20/32）. There was a significant difference of total effective rate between the two groups （ P 〈 0.05）. Compared to before treatment, GerdQ sores after treatment in both two groups decreased observation group ： （7.0 ± 2.0 ） points vs （ 9.8 ± 2.6 ） points ; control group ： （ 8.2 ± 2.0） points vs （ 10.3 ± 2.1 ）points ]. After treatment for 8 weeks, GerdQ sores in observation group was lower than that in control group （ P 〈 0.05 ）. Conclusion Combined therapy of lansoprazole and mosapride is effective in the treatment of NERD.