鸦胆子油乳注射液联合化疗治疗晚期非小细胞肺癌的近期疗效观察

目的 观察鸦胆子油乳注射液联合化疗治疗晚期非小细胞肺癌的临床效果.方法 将56例晚期非小细胞肺癌患者完全随机分为2组,单纯化疗组给予单纯化疗(紫杉醇加顺铂),联合组给予鸦胆子油乳注射液联合化疗(方案同单纯化疗组),治疗2个周期后评价疗效.结果 联合组和单纯化疗组患者有效率为分别39.3％(11/28)和35.7％(10/28),差异无统计学意义(P＞0.05),但临床受益率分别为82.2％(23/28)和71.4％(20/28),2组比较差异有统计学意义(P＜0.05),联合组患者生活质量明显高于单纯化疗组46.4％( 13/28)比28.6％( 8/28),P＜0.05],白细胞下降率明显低于单纯化疗组71.4％( 10/28)比85.7％(10/28),P＜0.05].结论 鸦胆子油乳注射液联合化疗治疗晚期非小细胞肺癌,可以提高患者的临床受益率,同时明显提高患者的生活质量,减轻化疗的毒副反应.

Brucea Javanica oil emulsion combined with paclitaxol and cisplantin in treatment of advanced-stage nonsmall cell lung cancer

Objective To observe the clinical effects of Brucea Javanica oil emulsion combined with paclit axol and cisplantin in treatment of advanced non-small cell lung cancer. Methods Fifty-six patients with advanced stage non-small cell lung cancer were randomized into group A （paclitaxol and cisplantin） and group B（ Brucea Javanica oil emulsion combined with paclitaxol and cisplantin）. Results The efficacy of two groups had no significances （P 〉0. 05） （group A with 35. 7% and group B with 39. 3% ）. But the clinical benefit rate bad significance （ group A with 71.4% and group B with 82. 2% ） （ P 〈 0. 05 ）. Patients in group B had the better quality of life and less droop rate of white blood cell than those in group A （ P 〈 0. 05 ）. Conclusion Using Brucea Javanica oil emulsion combined with paclitaxol and cisplantin can increase the clinical benefit rate, enhance the quality of life and relieve the side effects of chemotherapy in treatment of advanced non-small cell lung cancer.