骨肽注射剂致过敏性休克文献分析

目的 探讨骨肽注射剂致过敏性休克的临床特点及发生规律,为临床合理用药提供参考.方法 对2005-2010年中国期刊全文数据库进行检索,对其中涉及骨肽注射剂致过敏反应的25例病例报告进行统计与分析.结果 共检索到骨肽注射剂致过敏性休克的文献30篇,涉及患者25例.骨肽注射剂致过敏性休克患者(25例,261例次)的临床表现以心血管系统损害、中枢神经系统损害、呼吸系统损害较为多见.呼吸系统损害最多,占30.3％(79/261).其次为心血管系统损害,占19.9％ (52/261);中枢神经系统占18.0％(47/261).结论 骨肽注射剂导致过敏性休克发生时间短,多在用药过程中半小时内发生,病情危重,以呼吸系统、心血管系统和中枢神经系统损害多见.骨肽注射剂自身因素是导致过敏性休克的主要原因,应引起临床高度重视.

Analysis of anaphylactic shock induced by Gutai injection

Objective To study clinic features and regularity of anaphylactic shock induced by Gutai injec- tion and to provide reference for rational use of drug. Methods Twenty-five cases of allergic reaction induced by Gutai injection were collected and analyzed from China National Knowledge Infrastructure（CNKI） articles in 2005- 2010. Results All 30 articles of anaphylactic Gutai injection,including 25 patients, were analyzed. The damage of cardiovascular system central nervous system and respiratory system were common in anaphylactic shock with Gutai injection. Respiratory system harms were up to 30.3% （79/261）. Secondly the cardiovascular system harms were up to 19.9% （ 52/261 ） ; central nervous system was up to 18.0% （47/261）. Conclusion The duration of anaphy- lactic shook with Gutai injection is short. It usually happens within 30 minutes after injection and critical illness.