参芪扶正注射液降低阻塞性黄疸术后肝损伤的临床观察

目的 观察参芪扶正注射液对阻塞性黄疸患者手术后肝功能影响.方法 选取2009年5月至2011年3月重庆市巴南区中医院阻塞性黄疸患者42例,手术后将其完全随机分为对照组(22例)和观察组(20例),对照组给予早期肠内营养,首次500 ml/d,逐渐增加至1000 ml/d；观察组在此基础上加用参芪扶正注射液静脉滴注,250ml/次,1次/d.观察术前、术后1d和术后7d营养状况及肝功能状况及不良反应等.结果 观察组术后7d肝功能指标ALT、AST、总胆红素(TBil)分别为(35±19) U/L、(32±16) U/L、(27±9)μmol/L,对照组分别为(51±18)U/L、(51±1)U/L、(41±9)μmol/L,2组间差异有统计学意义(P＜0.05).2组患者手术前后营养状况指标差异均无统计学意义(P＞0.05).结论 参芪扶正注射液对阻塞性黄疸术后肝功能具有改善作用.

Treatment of liver injury after obstructive jaundice patients with Shenqifuzheng injection

Objective To observe the clinical effect of shenqifuzheng injection on the liver function of ob- structive jaundice patients after operation. Methods Forty-two patients from May 2009 to March 2011 in our hospi- tal were randomly divided into observation group（20 cases） and control group（22 cases）. The control group were treated with early enteral nutrition （EEN）. EEN were administrated 500 ml/d at the beginning then the dose was gradually up to 1000 ml/d, while the observation group was treated with additional shenqifuzheng injection for 7 days ,250 ml per day. Results The liver function indexes of alanine aminotransferase （ALT）, aspartate aminotrans-ferase （AST） and total bilirubin （TBil） were （35 ±19）U/L, （32±16）U/L, （27±9）μmol/L in observation group 7 days after operation; they were （51±18 ）U/L, （51±1 ）U/L, （41±9）μmol/L respectively in control group 7 days after operation ; the difference between the two groups was significant （ P 〈 0. 05 ）. The nutritional status of pre- operation and postoperation between the observation group and control group was not statistically significant （P 〉 0. 05）. Conclusion Treating the liver injury after obstructive jaundice patients with shenqifuzheng injection is effective.