| I型干扰素信号通路与系统性红斑狼疮发病机制的研究进展 |
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| 引用本文： | 李连红,叶冬青.I型干扰素信号通路与系统性红斑狼疮发病机制的研究进展[J].国际免疫学杂志,2009,32(3):193-197. |
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| 作者姓名： | 李连红 叶冬青 |
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| 作者单位： | 安徽医科大学公共卫生学院流行病与卫生统计学系,合肥,230032 |
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| 基金项目： | 国家自然科学基金，安徽省自然科学基金 |
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| 摘 要： | 系统性红斑狼疮（SLE）是一种常见的自身免疫性疾病，多数患者血清中干扰素-α（IFN-α）水平升高，并且在淋巴细胞和组织中出现大量IFN诱导应答基因。含有核酸的免疫复合物作为IFN—α的诱导物，结合外源性因素的作用，可激活体内依赖Toll样受体（TLR）和不依赖TLR等多条信号通路，刺激产生更多的IFN-α，形成恶性循环，启动和维持SLE的自身免疫过程。
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| 关 键 词： | 系统性红斑狼疮 IFN-α I型IFN |
Research advances in the study of type I interferon pathways in the pathogenesls of systemic lupus er-ymematosus |
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| LI Lian-hong,YE Dong-qing.Research advances in the study of type I interferon pathways in the pathogenesls of systemic lupus er-ymematosus[J].International Journal of Immunology,2009,32(3):193-197. |
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| Authors: | LI Lian-hong YE Dong-qing |
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| Institution: | . (Department of Epidemiology and BiostatistiCs , School of Public Health, Anhui Medical University, ttefei 230032, China) |
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| Abstract: | Systemic lupus erythematosus(SLE)is a common autoimmune disease and many SLE patients show increased serum IFN-α and over-expression of IFN-responsive genes in leukocytes and target tissues.As the inducers of IFN-α.nucleic acid-containing immune complexes accompanied with exogenous triggers could activate type I IFN pathways(TLR-dependent and TLR-independent)and then result in elevated IFN-α production and establish a vicious circle,which launches and maintains the autoimmune process of SLE. |
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| Keywords: | Systemic lupus erythematosus Interferon-α IFN-I |
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