急性脑外伤患者脑脊液髓鞘碱性蛋白水平与其损伤类型的关系

目的 探讨急性脑外伤患者脑脊液髓鞘碱性蛋白(CSF-MBP)水平与其损伤类型的关系。 方法 采用放射免疫测定法(RIA)对42例急性脑外伤患者的CSF-MBP进行测定,并测定26例非神经系统疾病患者作对照。结果 严重脑内原发性损伤患者CSF-MBP平均水平显著高于轻中度脑内原发性损伤和单纯颅内血肿者(P<0.01),单纯颅内血肿患者CSF-MBP仅伤后第5天增高;弥漫性脑损伤组CSF-MBP水平显著高于局灶性脑损伤组(P<0.01),伤后1周内持续处于高水平状态。结论 CSF-MBP的测定有助于急性脑外伤患者损伤程度及类型的判定。

Relationship between myelin basic protein levels in cerebrospinal fluid and injury type of patients with acute head injury

Objective To explore the relationship between myelin basic protein levels in cerebrospinal fluid (CSF - MBP) and injury type patients with acute head injury. Methods The levels of CSF - MBP in 42 patients with acute head injury and 26 patients with non nervous system diseases (as control) were measured by radioimmunoassay. Results The CSF -MBP levels were significantly higher in patients with severe intracerebral damage than in patients with moderate intracere-bral damage and in the ones with intracranial hematoma alone at 1st week after injury( P < 0.01). The CSF - MBP levels in patients with intracranial hematoma alone were only raised at 5th day after injury. The CSF - MBP levels in patients with diffuse brain damage were much higher than those in patients with focal brain damage in one week after injury ( P < 0.01) . Conclusions Determination of the CSF - MBP levels is helpful to assess injury severity and type of injury in patients with acute head injury.