Anticonflict actions of aqueous extracts of flowers of Achillea millefolium L. vary according to the estrous cycle phases in Wistar rats |
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Authors: | Molina-Hernandez M Tellez-Alcantara N P Diaz M A Perez Garcia J Olivera Lopez J I Jaramillo M Teresa |
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Institution: | Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México. mimoli@todito.com |
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Abstract: | Anticonflict-like effects of aqueous extract of flowers of Achillea millefolium L., a plant with purported anxiolytic actions, were studied in female Wistar rats during late proestrus or diestrus. During late proestrus (p < 0.05), control rats displayed reduced conflict behavior compared with diestrus. Diazepam (2.0 mg/kg; i.p.) reduced conflict behavior both during late proestrus (p < 0.05) or diestrus (p < 0.05). Doses of 8.0 mg/kg (p < 0.05), 10.0 mg/kg (p < 0.05) or 12.0 mg/kg (p < 0.05) of Achillea millefolium reduced conflict behavior during late proestrus. Conversely, during diestrus, only the dose of 12.0 mg/kg (p < 0.05) of Achillea millefolium L. reduced conflict behavior. In conclusion, the anticonflict-like actions of Achillea millefolium L. may vary according to the estrous cycle phase. |
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Keywords: | Achillea millefolium L anxiety‐like con?ict behavior diazepam estrous cycle |
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