Leucocyte distribution during sevoflurane anaesthesia |
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| Authors: | Morisaki, H. Aoyama, Y. Shimada, M. Ochiai, R. Takeda, J. |
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| Affiliation: | Department of Anaesthesiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan |
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| Abstract: | We have examined if sevoflurane anaesthesia per se modified the number ofcirculating leucocytes in humans. Fifty-nine patients undergoing electivesurgery were anaesthetized with sevoflurane in oxygen. The inhaledconcentration was increased gradually to 5% and maintained for 20 min.Arterial blood samples were obtained before induction of anaesthesia and at20 min. While the total number of leucocytes remained constant, circulatingneutrophils decreased (mean 3370 (SD 1030) mm-3 to 3170 (940) mm-3; P <0.01) and lymphocytes increased (1870 (520) mm-3 to 2040 (580) mm-3; P <0.01). We conclude that high concentrations of sevoflurane modified thedistribution of leucocytes in anaesthetized patients. |
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