脂肪酸结合蛋白4/5双重抑制剂的研究进展

脂肪酸结合蛋白（FABPs）是一类低相对分子质量的脂质伴侣蛋白，在调节糖脂代谢和炎症反应中发挥重要作用。研究表明，同时抑制FABP4/5能够显著改善由代谢应激引起的脂质代谢紊乱，缓解慢性代谢性炎症反应。近年来，FABP4/5受到广泛关注，被认为是代谢性疾病（如2型糖尿病、动脉粥样硬化和脂肪肝等）治疗药物研发的潜在靶标。综述FABP4/5双重抑制剂的最新研究进展，重点介绍FABP4/5与相关疾病的关系、抑制剂的构效关系以及蛋白共晶结构等方面内容，以期为设计全新结构的FABP4/5双重抑制剂提供参考依据。

Research Progress in Dual Inhibitors of Fatty Acidbinding Protein 4 and 5

Fatty acid-binding proteins (FABPs) are a group of intracellular lipid chaperones with low molecular weight that play important roles in regulating the metabolism of glucose and lipid and inflammatory responses. Studies have shown that simultaneous inhibition of both FABP4 and FABP5 can significantly improve metabolic stress-induced disorders of lipid metabolism, and attenuate chronic metabolic inflammation. In recent years, FABP4 and FABP5 have attracted much attention as potential targets for developing drugs for metabolic diseases (such as type 2 diabetes, atherosclerosis and fatty liver, et al). This article summarized the latest research progresses in dual inhibitors of FABP 4 and 5 with a focus on the correlation between FABP4/5 and diseases, structure-activity relationship of the inhibitors and the crystal structures of protein-inhibitor complexes, so as to provide reference for the design of novel FABP4/5 dual inhibitors.