冠心病并抑郁患者血浆NPY、NE、DA、5-HT的变化及其临床意义

目的探讨冠心病合并抑郁障碍患者血浆神经肽Y、去甲肾上腺素、多巴胺、5-羟色胺水平的变化及其临床意义。方法66例经选择性冠状动脉造影确诊为CHD的住院病人，通过Zung抑郁自评量表问卷调查分为抑郁障碍组（抑郁组，36例）和对照组（不伴抑郁障碍，30例）。统计其年住院次数及年住院天数，并分别运用放射免疫法和免疫荧光法检测患者血浆NPY和NE、DA、5-HT的含量。结果①与CHD患者比较，合并抑郁障碍的CHD患者年住院次数及年住院天数均明显增多，具有统计学差异（P〈0．05）；②与CHD患者比较，合并抑郁障碍的CHD患者血浆NPY、NE、DA水平均显著增高，具有统计学差异（P〈0．05）；血浆5-HT水平均显著降低，具有统计学差异（P〈0．05）。结论①合并抑郁障碍的CHD患者年住院次数及天数明显增加，应引起临床医生尤其是心血管医师的高度重视；②血NPY、NE、DA、5-HT的异常增加可能参与了改变CHD患者抑郁障碍的发生发展过程。

Study on the Change of Pasma NPY,NE,5-HT,DA in CHD with Depression Neurosis

Objective To explore the change of plasma neuropeptide Y（ NPY ）, norepinephrine（ NE ）, 5-hydroxytryptamine （5-HT）, dopamine （DA）in coronary heart disease（ CHD ）with depression neurosis. Methods In-patients diagnosed by Coronary angiography, separated 30 eases as control group and 36 cases as depression group by Self-Rating Depression Seale（SDS）. Using Radioimmunoassay method to detect the plasma NPY and immumotluoreseenee method to detect the content of plasma NE, DA,5-HT. Results The levels of plasma NPY,DA and NE were higher in CHD with depression while the plasma 5-HT were lower than those in ecumenic CHD patients（ P 〈 0.05 ）. Conclusion The plasma NPY,DA, NE and 5-HT were probably attached to the pathophysiologie process of CHD with depression.