| MUC1在肾癌中的表达及意义 |
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| 引用本文： | 李威武,李培军,张宁妹,秦璟.MUC1在肾癌中的表达及意义[J].宁夏医学杂志,2009,31(6). |
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| 作者姓名： | 李威武 李培军 张宁妹 秦璟 |
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| 作者单位： | 1. 宁夏医科大学,宁夏,银川,750004
2. 宁夏医科大学附属医院,宁夏,银川,750004 |
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| 摘 要： | 目的 探讨多态性上皮黏蛋白1(MUC1)在肾癌中的表达及临床意义.方法 采用免疫组化方检测40例肾癌组织和10例癌旁组织及10例正常组织中MUC1的表达.结果 正常组织中肾小管可见MUC1阳性表达,呈对称性及极性分布,而肾癌组织中,MUC1黏蛋白则大多呈弥漫性、失极性表达,染色程度增高,且多伴有胞浆中的表达.MUC1在肾癌中阳性表达率为85%(34/40),10例癌旁组织低表达1例,表达率为10%,具有统计学意义(χ2=21.429,P<0.05).MUC1在肾癌的不同病理类型表达差异无统计学意义(P>0.05),与不同病理分级和临床分期差异有统计学意义(P<0.05).术后转移组和未转移组之间差异有统计学意义(χ2=8.929,P<0.05).结论 MUC1在肾癌中表达可作为评估肾癌的恶性程度和预测术后转移的生物学指标.
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| 关 键 词： | 肾癌 免疫组织化 术后转移 |
The Clinical significance and the expression of MUC1 in renal cell carcinoma |
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| LI Wei-wu,et al..The Clinical significance and the expression of MUC1 in renal cell carcinoma[J].Ningxia Medical Journal,2009,31(6). |
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| Authors: | LI Wei-wu |
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| Institution: | The Affiliated Hospital of Ningxia Medical University;Yinchuan 750004;China |
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| Abstract: | Objective To investigate the clinical significance of the expression of MUC1 in renal cell carcinoma.Methods The proteins were detected by Immunohistochemical methods in 40 cases of renal cell carcinoma,10 cases of adjacent tissue,and 10cases of human renal tissue.Results All normal renal tissues expressed MUC1 mucin in the nephric tubule with distributn polarized apically,while in RCC diffused heterogeneous cytoplasmic and membranous over expression of MUC1 were observed.The positive rates in RCC were 85.0... |
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| Keywords: | MUC1 |
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