| 膀胱尿路上皮癌患者外周血T淋巴细胞凋亡蛋白Fas的表达 |
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| 引用本文： | 罗广承,刘莉莉,白培明,张楠根,颜志坚. 膀胱尿路上皮癌患者外周血T淋巴细胞凋亡蛋白Fas的表达[J]. 中华实验外科杂志, 2008, 26(1): 920-921. DOI: 10.3760/cma.j.issn.1001-9030.2009.07.039 |
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| 作者姓名： | 罗广承 刘莉莉 白培明 张楠根 颜志坚 |
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| 作者单位： | 厦门大学附属中山医院泌尿外科福建医科大学教学医院,361004;厦门大学附属中山医院泌尿外科检验中心,361004; |
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| 摘 要： | Objective To investigate the relationship between the Fas expression in peripheral blood T cells and bladder transitional cell carcinoma (TCC). Methods The Fas expression in peripheral blood T cells of 52 patients with TCC and 37 healthy people was detected by flowcytometry. The Fas-posi-tive rate was compared by t test between two designed groups. Results The Fas expression in CD4+ [(20.74±9.02)%] and CD8+[ (7.51±5.93 )% ] was increased in TCC patients as compared with controls ( P < 0. 01 ). Fas-positive CD8+ ceils were reduced in invasive TCC as compared with superficial TCC [ ( 5. 83±3.95 ) % vs ( 5. 83±3.95 ) %, P < 0.05 ], but there was no difference between primary and recurrent cases ( P > 0.05 ). Conclusion The abnormal Fas expression in peripheral blood T cells may play an important role in the development and progression of TCC.
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| 关 键 词： | 膀胱肿瘤 Fas蛋白 淋巴细胞 脱噬作用 |
Expression of Fas in peripheral blood T lymphocytes in patients with bladder urothelial carcinom |
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| Abstract: | |
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| Keywords: | Bladder neoplasmFas proteinLymphocyteApoptosis |
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