老年COPD患者肺功能与骨密度及维生素D关系

目的:探讨老年慢性阻塞性肺疾病(COPD)患者肺功能与骨密度及维生素D之间的关系?方法:COPD患者104例(男61例,女43例),对照组100例为同时期同年龄阶段同性别比例住院非COPD老年患者,检测肺功能?测定腰椎1~4?股骨颈骨密度?血清维生素D,比较不同肺功能组患者骨密度?维生素D水平的关系?结果:老年患者存在维生素D不足及骨量减少,COPD组患者维生素D缺乏症及骨质疏松症高于对照组(37.5% vs 16.0%,38.5% vs 20.0%,P < 0.05),肺功能恶化伴随股骨颈骨量减少及维生素D缺乏(P < 0.05)?相关性分析表明骨密度及维生素D与FEV1成线性正相关(P < 0.05)?结论:老年COPD患者易合并维生素D缺乏症及骨质疏松症,随着肺功能恶化,患病率增加;骨密度值及维生素D与肺功能呈正相关性?

Relationship between lung function and bone mineral density,serum Vitamin D in elderly patients with chronic obstructive pulmonary disease

Objective:To study the relation shipbetween lung function and bone mineral density(BMD),serum Vitamin D in elderly patients with chronic obstructive pulmonary disease(COPD). Methods:Pulmonary function,BMD of lumbar spine and femoral neck,and serum Vitamin D were determined in 104 COPD(61 male,43 postmenopausal female) patients and 100 cases age and sex matched non-COPD controls. The association of lung function and BMD with serum vitamin D was analyzed as well. Results:Vitamin D insufficient and osteopenia were present in elderly men.The prevalence of Vitamin D deficiency and osteoporosis was higher in COPD group than that in non-COPD controls (37.5% vs 16.0% and 38.5% vs 20.0%)(P < 0.05). The increase of COPD severity led to the decrease of average values of BMD of femoral neck (P < 0.05),as well as Vitamin D (P < 0.05). Correlation analysis showed that BMD and Vitamin D were correlated to FEV1(P < 0.05). Conclusion:Prevalence of Vitamin D deficiency is high in COPD patients,increases with the severity of COPD,and is closely associated with osteoporosis prevalence. BMD and Vitamin D were correlated to pulmonary function.