根据卵泡输出率评估IVF中卵巢的反应性及结局

目的:研究在体外受精-胚胎移植(IVF-ET)中,卵泡输出率(follicular output rate,FORT)对卵巢反应性的评估能力及对妊娠结局的预测能力?方法:共研究3 292例控制性超排卵患者,每位患者均以外源性重组卵泡刺激素(recombinant follicle stimulating hormone,rFSH) 225 iu启动?根据FORT值将其分为低?中?高3组?回顾性研究了3组间控制性超排卵数据及实验室指标?结果:窦卵泡数(antral follicle count,AFC)在高FORT组最低,在低FORT组最高?排卵前卵泡数(preovulatory follicle count,PFC)及注射人体绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)日当天雌二醇 (estradiol,E2)在高FORT组中最高,在低FORT组中最低?获卵数?总胚胎数?优质胚胎数在低?中?高3组间逐步升高,差异有统计学意义?而胚胎种植率及临床妊娠率在3组间亦有统计学差异,在高FORT组中最高?结论:FORT是研究卵巢反应性的有力工具,高FORT组将具有更好的妊娠结局?

Assessing the reactivity of ovary and its outcome in IVF based on follicular output rate

Objective:To evaluate the activity of FORT on assessing ovarian response and predicting pregnancy outcome by FORT in IVF-ET. Methods:Three thousand and two hundred and nighty-two patients of controlled ovarian stimulation,divided into low,medium and high groups based on FORT,were investigated and each activated by rFSH 225 U. The controlled ovarian stimulation data of these patients and their laboratory index were analyzed. Results:Antral follicle count (AFC) is the lowest in the high FORT group and the highest in the low FORT group,preovulatory follicle count (PFC),as well as E2 with injection of HCG in the same day,are the highest in the high FORT group and the lowhest in the low FORT group. The number of retrieved oocytes,the total number of embryos and the number of high quality embryos escalate increased consistently with the FORT in these group,and the differences were significant amony group amparison comparison. Meanwhile,the embryo implantation rate and the clinical pregnancy rate also differ statistically in these groups and reach to the highest level in the high FORT group. Condusion:FORT is an important tool to study the reactivity of ovary. The high FORT group has better pregnancy outcome.