角膜穿孔临床研究分析

目的：研究角膜穿孔(corneal perforation，CP)患者的临床发病特点。

方法：回顾性分析1995-07/2010-07福建医科大学附属第一医院住院确诊的CP患者72例72眼，分析其患者临床特点。

结果：福建地区角膜溃疡穿孔发病率逐年上升，男女发病率比为 17：7 ， 48岁为发病集中年龄，产业工人 23例(32%)，23例有明确外伤史，菌属鉴定结果：前两位为：真菌感染和棘阿米巴原虫感染。 其中10例有糖皮质激素用药史。

结论：外伤、真菌性、棘阿米巴角膜炎、蚕食性角膜炎等所致CP的原发病因多种多样，福建地区CP多发于中老年的男性，多数外伤为诱因，致病菌属以真菌感染为主。

Clinical research on corneal perforation

AIM: To study the clinical characteristics of corneal perforation(CP).

METHODS: A retrospective analysis in July 1995 to July 2010 the First Affiliated Hospital of Fujian Medical University diagnosed CP 72 patients(72 eyes), clinical characteristics of all the patients were analyzed.

RESULTS: The incidence of corneal ulcer perforation rised year by year, the morbidity of male and female was 17:7, the onset age focused on 48 years old. Of 23 industrial workers(32%)with clear history of trauma, pathogeny identification results: top two: fungal infection and Acanthamoeba keratitis. A using history of glucocorticoid was found in 10 cases.

CONCLUSION: There are plenty of primary causes of CP such as traumas, fungal infection, Acanthamoeba keratitis, eroded keratitis, etc. CP happens in middle-aged males in Fujian province, most traumas are the causes, the main pathogenic bacteria is fungal infection.