首页 | 本学科首页   官方微博 | 高级检索  
按 检索        


Correlation of breast cancer subtypes,based on estrogen receptor,progesterone receptor,and HER2, with functional imaging parameters from 68Ga-RGD PET/CT and 18F-FDG PET/CT
Authors:Hai-Jeon Yoon  Keon Wook Kang  In Kook Chun  Nariya Cho  Seock-Ah Im  Sunjoo Jeong  Song Lee  Kyeong Cheon Jung  Yun-Sang Lee  Jae Min Jeong  Dong Soo Lee  June-Key Chung  Woo Kyung Moon
Institution:1. Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea
11. Department of Nuclear Medicine, Ewha Womans University School of Medicine, Seoul, Korea
6. The Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea
5. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
8. Cancer Research Institute, Seoul National University, Seoul, Korea
12. Department of Nuclear Medicine, Kangwon National University Hospital, Chuncheon, Kangwon-Do, Korea
2. Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea
3. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
10. Department of Molecular Biology, Dankook University, Yongin, Korea
4. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea
7. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University College of Medicine, Seoul, Korea
9. Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea
Abstract:

Purpose

Imaging biomarkers from functional imaging modalities were assessed as potential surrogate markers of disease status. Specifically, in this prospective study, we investigated the relationships between functional imaging parameters and histological prognostic factors and breast cancer subtypes.

Methods

In total, 43 patients with large or locally advanced invasive ductal carcinoma (IDC) were analyzed (47.6?±?7.5 years old). 68Ga-Labeled arginine-glycine-aspartic acid (RGD) and 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) were performed. The maximum and average standardized uptake values (SUVmax and SUVavg) from RGD PET/CT and SUVmax and SUVavg from FDG PET/CT were the imaging parameters used. For histological prognostic factors, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression was identified using immunohistochemistry (IHC) or fluorescent in situ hybridization (FISH). Four breast cancer subtypes, based on ER/PR and HER2 expression (ER/PR+,Her2?, ER/PR+,Her2+, ER/PR?,Her2+, and ER/PR?,Her2?), were considered.

Results

Quantitative FDG PET parameters were significantly higher in the ER-negative group (15.88?±?8.73 vs 10.48?±?6.01, p?=?0.02 for SUVmax; 9.40?±?5.19 vs 5.92?±?4.09, p?=?0.02 for SUVavg) and the PR-negative group (8.37?±?4.94 vs 4.79?±?3.93, p?=?0.03 for SUVavg). Quantitative RGD PET parameters were significantly higher in the HER2-positive group (2.42?±?0.59 vs 2.90?±?0.75, p?=?0.04 for SUVmax; 1.60?±?0.38 vs 1.95?±?0.53, p?=?0.04 for SUVavg) and showed a significant positive correlation with the HER2/CEP17 ratio (r?=?0.38, p?=?0.03 for SUVmax and r?=?0.46, p?<?0.01 for SUVavg). FDG PET parameters showed significantly higher values in the ER/PR?,Her2? subgroup versus the ER/PR+,Her2? or ER/PR+,Her2+ subgroups, while RGD PET parameters showed significantly lower values in the ER/PR?,Her2? subgroup versus the other subgroups. There was no correlation between FDG and RGD PET parameters in the overall group. Only the ER/PR?,Her2? subgroup showed a significant positive correlation between FDG and RGD PET parameters (r?=?0.59, p?=?0.03 for SUVmax).

Conclusion

68Ga-RGD and 18F-FDG PET/CT are promising functional imaging modalities for predicting biomarkers and molecular phenotypes in breast cancer patients.
Keywords:
本文献已被 SpringerLink 等数据库收录！
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号