| 弥漫大B细胞性淋巴瘤分子亚型的蛋白表达及预后的相关研究 |
| |
| 引用本文： | 姚丽青,郑智勇,刘秉瀚,余英豪,申洪,曾玲.弥漫大B细胞性淋巴瘤分子亚型的蛋白表达及预后的相关研究[J].福州总医院学报,2008(Z1). |
| |
| 作者姓名： | 姚丽青 郑智勇 刘秉瀚 余英豪 申洪 曾玲 |
| |
| 作者单位： | 南京军区福州总医院病理科;福州大学数学与计算机科学学院;南方医科大学病理教研室; |
| |
| 基金项目： | 国家自然科学基金(编号：60372021); 福建省自然科学基金(编号：A0310010)资助 |
| |
| 摘 要： | 目的:在蛋白水平上研究国人弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)分子分型的蛋白表型特点,为DLBCL的病理诊断、预后和治疗提供依据。方法:取DLBCL标本52例行HE染色和免疫组化染色。在形态学分型的基础上,利用CD10、MUM1和bcl-6免疫标记对DLBCL进行分子分型,分为生发中心样B细胞样组(germi-nal center B-cell—like,GCB)和非生发中心样B细胞样组(non-germinal center B-cell-like,non-GCB),分析其在DLBCL中的构成比,及CD10、MUM1和bcl-6的表达情况。结果:本组DLBCL中,non-GCB的构成比超过GCB(69.2%/30.8%);统计学分析表明,GCB组间CD10、bd-6、CD10/bcl-6的表达率的差异有显著性意义,其中CD10的表达率最高,bcl-6其次,CD10/bcl-6最低;non-GCB组间MUM1、MUM1/bcl-6的表达率的差异有显著性意义。结论:我国的DLBCL多起源于后生发中心B细胞,以non-GCB为主,预后较差。DLBCL在CD...
|
| 关 键 词： | DLBCL 分子亚型 免疫组化 形态学亚型 预后 |
Investigation of the characteristics of protein phenotypes of diffuse large B-cell lymphoma of different molecule types |
| |
| Yao Liqing Zheng zhiyong Liu Binghan et al.Investigation of the characteristics of protein phenotypes of diffuse large B-cell lymphoma of different molecule types[J].Journal of Fuzhou Genenal Hospital,2008(Z1). |
| |
| Authors: | Yao Liqing Zheng zhiyong Liu Binghan |
| |
| Institution: | Yao Liqing Zheng zhiyong Liu Binghan et al Department of pathology,Fuzhou general hospital,fuzhou |
| |
| Abstract: | Objective:TO investigate the characteristics of protein phenotypes of diffuse large B-cell lymphoma of differ- ent molecule types in Chinese people so as to provide evidence for the pathological diagnosis,treatment and prognosis of DLBCL. Method:Fifty-two cases of DLBCL were selected to perform HE staining and immunochemical staining.On the basis of morpho- logical typing,the cases of DLBCL were further subtyped molecully into germinal center B-cell-like and non-germinal center B -cell-like groups using CD1... |
| |
| Keywords: | DLBCL Molecule Immunochemical Morphological prognosis |
| 本文献已被 CNKI 等数据库收录！ |
|
