The amino acid sequence of a mammalian MAP kinase kinase. |
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| Authors: | A Ashworth S Nakielny P Cohen C Marshall |
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| Institution: | Chester Beatty Laboratories, Institute of Cancer Research London. |
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| Abstract: | The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae. |
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