一种复方草药胶囊的含量测定以及与标准汤剂的制备比较(英)

为了评估一种治疗过敏性鼻炎的草药复方胶囊剂并控制其质量,制定了HPLC法测定其中黄芩苷的方法,考察了该法的有效性并将该法应用于测定胶囊剂及其原汤剂中的该有效成分.试验表明用热沸水从草药提取黄芩苷是一种有效的制备方法;与浸膏混合的黄芩苷在水中的溶解度达(1.56mg·mL-1)(37℃);在标准汤剂每日剂量中该标志成分的含量大大高于胶囊剂每日剂量中的含量.结果提示,浓缩的草药制剂应与其原标准汤剂在化学和药剂进行比较以便进一步优化处方及其产品.

Assay of a formulated herbal capsule and comparison of preparation with the standard decoction

A HPLC method for determination of baicalin in a formulated herbal capsule, which was used in treatment of perennial allergic rhinnitia, was established to evaluate the new preparation and to control its quality.Validation tests were studied and the method was applied for assay of the active component in the capsules and its original standard decoction. The experiment shows that extraction of baicalin with hot or boiling water from when it was mixed in the extract. The content of the marker component in the standard decoction of daily dose was found to be much higher than those in concentrated herbal capsules. The result indicates that a concentrated herbal preparation should make a comparison of chemistry and efficacy with its original standad decoction to optimizing the herbal formula and its product.