Short-course antibiotics for prosthetic joint infections treated with prosthesis retention |
| |
Authors: | Puhto A-P Puhto T Syrjala H |
| |
Institution: | 1. Division of Orthopaedic and Trauma Surgery, Department of Operative Care, Oulu University Hospital, Oulu, Finland;2. Department of Infection Control, Department of Operative Care, Oulu University Hospital, Oulu, Finland |
| |
Abstract: | The purpose of the present study was to evaluate the significance of shortening the antibiotic treatment duration in prosthetic joint infections (PJI) treated with debridement, antibiotics and implant retention (DAIR). In April 2006 we shortened the total antibiotic treatment duration in total knee arthroplasty (TKA) PJIs from 6 months to 3 months and in total hip arthroplasty (THA) PJIs from 3 months to 2 months. All patients with TKA or THA PJI treated with DAIR between February 2001 and August 2009 were reviewed retrospectively. There were 132 patients treated with DAIR, of whom 86 (65%) completed the antibiotic therapy and were therefore eligible for comparison concerning the length of antibiotic treatment. There were 32 (37%) THA and 54 (63%) TKA PJIs in the comparison. The treatment succeeded in 34 (89.5%) patients treated with longer antibiotic treatment and in 42 (87.5%) of those treated with shorter antibiotic treatment (p 0.78). Our conclusion is that if the patient completes the antibiotic therapy, treatment duration of 3 months in TKA PJIs and 2 months in THA PJIs is as good as longer antibiotic treatment of 6 months or 3 months, respectively, in patients treated with DAIR. |
| |
Keywords: | Antibiotic treatment duration antimicrobial treatment orthopaedic implant infection prosthetic joint infection total joint arthroplasty |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|