| SalB stimulates neurogenesis and angiogenesis in vitro and in vivo |
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| 引用本文： | 钟静 秦转弟 唐民科 程勇 张均田. SalB stimulates neurogenesis and angiogenesis in vitro and in vivo[J]. 中国药理通讯, 2005, 22(4): 9-10 |
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| 作者姓名： | 钟静 秦转弟 唐民科 程勇 张均田 |
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| 作者单位： | [1]Pharmacology Department, Beijing University of Chinese Medicine. [2]pharmacology Department, Institute of Materia Medica, Peking Union Medical College. |
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| 摘 要： | Aims： Previous studies suggested that Salvianolic acid B （SalB） has strong protective effect against cerebral ischemia. Recently, Sal B has been reported to enhance angiogenesis in vitro. Based on the information above, in this study we are interested in the effect of SalB on neurogenesis and angiogenesis. Methods：In vitro study, we used embryonic mouse （El6） primary cortical neural cultures. Neuron was recognized by anti-MAP2 with immunocytochemistry. Neurogenesis was tested with BrdU incorporation by ELSA method. SalB（ 10 -6 -10 -8M） or vehicle was added to the culture medium 24 hrs before BrdU addition. In vivo, middle cerebral artery occlusion （MCAO） rats were used as focal cerebral ischemia model.
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| 关 键 词： | 神经形成 神经凋亡 SalB 免疫细胞化学 脑部疾病 |
SalB stimulates neurogenesis and angiogenesis in vitro and in vivo |
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| Zhong Jing;Qin ZhuanDi;Tang MinKe;Cheng Yong;Zhang JunTian. SalB stimulates neurogenesis and angiogenesis in vitro and in vivo[J]. , 2005, 22(4): 9-10 |
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| Authors: | Zhong Jing Qin ZhuanDi Tang MinKe Cheng Yong Zhang JunTian |
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