SalB stimulates neurogenesis and angiogenesis in vitro and in vivo |
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作者姓名: | 钟静 秦转弟 唐民科 程勇 张均田 |
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作者单位: | [1]Pharmacology Department, Beijing University of Chinese Medicine. [2]pharmacology Department, Institute of Materia Medica, Peking Union Medical College. |
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摘 要: | Aims: Previous studies suggested that Salvianolic acid B (SalB) has strong protective effect against cerebral ischemia. Recently, Sal B has been reported to enhance angiogenesis in vitro. Based on the information above, in this study we are interested in the effect of SalB on neurogenesis and angiogenesis. Methods:In vitro study, we used embryonic mouse (El6) primary cortical neural cultures. Neuron was recognized by anti-MAP2 with immunocytochemistry. Neurogenesis was tested with BrdU incorporation by ELSA method. SalB( 10 -6 -10 -8M) or vehicle was added to the culture medium 24 hrs before BrdU addition. In vivo, middle cerebral artery occlusion (MCAO) rats were used as focal cerebral ischemia model.
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关 键 词: | 神经形成 神经凋亡 SalB 免疫细胞化学 脑部疾病 |
SalB stimulates neurogenesis and angiogenesis in vitro and in vivo |
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Authors: | Zhong Jing;Qin ZhuanDi;Tang MinKe;Cheng Yong;Zhang JunTian |
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