Caerulein and cholecystokinin suppress β-endorphin-induced analgesia in the rat |
| |
Authors: | Shinji Itoh Goro Katsuura Yumino Maeda |
| |
Institution: | Shionogi Research Laboratories, Fukushima-ku, Osaka 553, Japan |
| |
Abstract: | The analgesic action of β-endorphin, as observed in the hot plate test with rats, was effectively suppressed by intracerebroventricular (i.c.v.) injection of caerulein and cholecystokinin octapeptide (CCK-8). The effect of caerulein was particularly striking; this peptide in doses of more than 0.09 nM lessened or abolished the analgesic effect of β-endorphin in a dose of 0.7 nM. On the other hand, non sulfated CCK-8 had no significant effect on β-endorphin-induced analgesia. |
| |
Keywords: | Cholecystokinin Caerulein β-Endorphin Analgesia |
本文献已被 ScienceDirect 等数据库收录! |