Incidental langerhans cell histiocytosis of thyroid: case report and review of the literature |
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| Authors: | Foulet-Rogé Armelle Josselin Nicolas Guyetant Serge Gardet Jean-Jacques Besancon Anne Saint-André Jean-Paul Fabiani Bettina |
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| Institution: | (1) Department of Surgery, General Hospital, Le Mans Cedex, France;(2) Department of Internal Medicine, General Hospital, Le Mans Cedex, France;(3) Department of Pathology, CHU, Angers Cedex, France;(4) Department of Pathology, General Hospital, 194 avenue Rubillard, 72037 Le Mans Cedex, France |
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| Abstract: | We report a case of a 42-yr-old woman with Langerhans cell histiocytosis (LCH) confined to the thyroid and associated with
lymphocytic thyroiditis and a papillary microcarcinoma. This patient remains free of symptoms 14 mo after surgery. Thyroid
LCH is rare. In children, it usually occurs as part of a multisystemic disease, whereas it is usually exclusive in adults.
Isolated thyroid LCH is frequently associated with another thyroid disease, especially lymphocytic thyroiditis, suggesting
that it is a reactive process rather than a neoplastic proliferation. The prognosis of isolated thyroid LCH is good. However,
because it can rarely precede or reveal a multisystemic disease, additional investigations as well as a prolonged follow-up
are justified. |
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| Keywords: | Thyroid gland Langerhans cell histiocytosis lymphocytic thyroiditis papillary carcinoma |
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