我国南亚热带地区(南澳县)恙虫病疫源地的证实

目的　我国广东省南澳县恙虫病发病率近年明显增高 ,而国内关于此疫源地的记录极少。本研究对该地区恙虫病疫源地进行全面研究。方法　疫源地流行病学调查 ,病原分离鉴定与分子生物学研究 ,预防措施的制定。结果　该地区为南亚热带岛屿疫源地 ,主要宿主为褐家鼠 ,主要媒介为地里纤恙螨 ,褐家鼠与地里纤恙螨的季节消长与发病均一致。从宿主与媒介分离到恙虫病立克次体经鉴定为 Karp株。分子生物学结果与鉴定结果基本一致同时还证明存在 Kato株与韩国地方株(Yonchon)。血清流行病学调查表明该地区居民与部队人群均存在恙虫病立克次体抗体。在流行季节前应用综合预防措施当年无病例发生。结论　我国南澳县是恙虫病疫源地

THE CONFIRMATION OF THE EPIDEMIC AREA OF TSUTSUGAMUSHI DISEASE ON NAN'AO COUNTY IN CHINA

Aim\ Recent years the incidence of tsutsugamushi disease has increased on the Nan ao county in China and the characteristic of the epidemic area has not been reported.This study has investigated the region for the epidemic area of tsutsugamushi disease.Methods\ The investigation of the epidemic area,the isolation of Orientia tsutsugamushi,the study of pervention measures were carried out.Results\ The region is the island epidemic area of south subtropical zone.The main host is Rattus norvegicus.The main biological vector is Leptotrombidium (Leptotrombidium) deliens.The seasonal quantity trends of Rattus norvegicu and Leptotrombidium (Leptotrombidium) deliens are consistent with the incidence of the disease of the region.The Orientia tsutsugamushi has been isolated from Rattus norvegicus and Leptotrombidium (Leptotrombidium) deliens.The results of identification show that Orientia tsutsugamushi isolated strains is mainly Karp.The molcular biological results show that Kato and Korea strain (Yonchon) is present in the region.The serologic results show that antibody to Orientia tsutsugamushi is positive in the residents and army crowd.After the prevent measures were carried out,the incidence was descent.Conclusion\ The Nanao county is the epidemic area of tsutsugamushi disease.