丹参滴丸对肾性高血压兔离体冠状动脉环的影响

目的观察丹参滴丸对肾性高血压兔离体冠状动脉环舒缩功能的影响并探讨其作用机制。方法肾性高血压兔离体冠状动脉环标本随机分为模型组、维拉帕米组、丹参滴丸组,以去甲肾上腺素（NE）灌流离体兔冠状动脉环,观察丹参滴丸对去甲肾上腺素致离体肾性高血压兔冠状动脉环舒缩功能的影响。结果丹参滴丸可抑制去甲肾上腺素引起的离体肾性高血压兔冠状动脉收缩,10^-3～10^-2mol/L丹参滴丸可使去甲肾上腺素引起的内源性钙收缩张力分别下降至（0.51±0.07）g和（0.86±0.08）g,其降低百分率（（16.29±6.39）%、（27.58±6.97）%）,与维拉帕米组比较差异有统计学意义（P均〈0.05）。结论丹参滴丸可抑制血管平滑肌细胞受体操纵钙通道介导的外钙内流及血压依赖性钙通道的内钙释放,这与其临床治疗冠心病的作用机制一致。

Effect of Danshen dripping pills on coronary artery rings isolated from hypertensive rabbits

Objective It is to observe the effect of Danshen dripping pill on the vasomotor function of coronary artery rings isolated from hypertensive rabbits. Methods The samples of coronary artery rings isolated from hypertensive rabbits were randomly divided into model group,verapamil group,Danshen dripping pill group,The rins were simulated by perfusion with norepinephrine（ NE） to observe the effect of Danshen dripping pill on the vasomotor function of coronary artery rings isolated from hypertensive rabbits. Results Danshen dripping pill could inhibit the vasomotor function of coronary artery isolated from hypertensive rabbits induced by NE,and 10^- 3- 10^- 2mol /L Danshen dripping pill could decrease the endogenous calcium contraction induced by NE to（ 0. 51 ± 0. 07） g and（ 0. 86 ± 0. 08） g,the decreasing percentage were（（ 16. 29 ± 6. 39） %,（ 27. 58 ±6. 97） %）,compared with those in verapamil group,the differences were significant（ P〈0. 05）. Conclusion Danshen dripping pill could inhibit external calcium inter-influx and intracellular calcium release mediated by receptor operated cnlcium channel of vascular smooth muscle cell gymnastics longitudinal calcium channels which can inhibit.