前列地尔联合α-硫辛酸、甲钴胺对糖尿病周围神经病变的临床疗效观察

目的：观察前列地尔联合α-硫辛酸、甲钴胺治疗2型糖尿病周围神经病变的临床疗效。方法：选择符合入选标准的2型糖尿病周围神经病变患者50例，除了给予常规药物控制血糖，均静脉滴注前列地尔10ug ，1次/天，α-硫辛酸600mg，1次/天，并静脉推注甲钴胺1mg，1次/天。连续用药2周。治疗前后分别记录TCSS评分，正中神经（MN）、腓总神经（CPN）的运动神经传导速度（MNCV）与感觉神经传导速度（SNCV）。结果：治疗后TCSS评分较治疗前显著降低（P＜0.05）；治疗后MNCV、SNCV与治疗前比较，差异具有统计学意义（P＜0.05）。结论：前列地尔联合α-硫辛酸、甲钴胺对2型糖尿病周围神经病变疗效显著。

Clinical Therapeutic Effect on Diabeticperipheral Neuropathy of Alprostadil Combined with Alpha Lipoic Acid and Mecobalamin

Objective： To observe the clinical curative effect of alprostadil combined with alpha lipoic acid and Mecobalamin on treating type 2 diabetic peripheral neuropathy. Methods： 50 patients with type 2 diabetic peripheral neuropathy were included. Besides routine drugs to control blood sugar, they all were treated with intravenous infusion of alprostadil 10ug, 1 times/day, alpha lipoic acid 600mg, 1 times/day, and intravenous injection of mecobalamin 1mg, 1 times/day;all medication were kept for two weeks consecutively. TCSS scores were recorded before and after treatment of the median nerve（MN）, common peroneal nerve （CPN） in motor nerve conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV）. Results： after treatment, TCSS scores decreased significantly （P＜0.05）;comparing the TCSS scores of MNCV and SNCV before and after the treatment, the difference was statistically significant （P＜0.05）. Conclusion： alprostadil combined with alpha lipoic acid and methylcobalamin has significant therapeutic effect on peripheral neuropathy in type 2 diabetic mellitus.