| 丹参酮ⅡA磺酸钠对肢体缺血再灌注后大鼠肺组织超微结构的影响 |
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| 引用本文： | 李志君,;孟庆春,;高淑杰,;赵秀花,;朱雅,;孔小燕.丹参酮ⅡA磺酸钠对肢体缺血再灌注后大鼠肺组织超微结构的影响[J].现代中西医结合杂志,2014(22):2409-2412. |
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| 作者姓名： | 李志君 ;孟庆春 ;高淑杰 ;赵秀花 ;朱雅 ;孔小燕 |
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| 作者单位： | [1] 河北港口集团有限公司港口医院,河北秦皇岛066000; [2]河北联合大学,河北唐山063000 |
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| 摘 要： | 目的探讨丹参酮ⅡA磺酸钠对大鼠肢体缺血再灌注后肺组织超微结构的影响。方法将60只雄性SD大鼠随机分成假手术组(A组)、单纯缺血再灌注组(B组)和丹参酮ⅡA磺酸钠组(C组)。采用常规法建立大鼠肢体缺血再灌注损伤模型。利用光镜和电镜观察肺组织形态学改变和超微结构改变,利用比色法测定肺组织中MDA、SOD、XOD水平,并进行比较。结果与B组相比,C组肺血管扩张、炎性细胞聚集、组织损伤明显减轻;肺组织MDA、XOD活力明显降低,SOD活力升高。结论丹参酮对肢体缺血再灌注后肺组织结构具有明显的保护作用。
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| 关 键 词： | 肺缺血再灌注 超微结构 丹参酮ⅡA磺酸钠 大鼠 |
Effect of sodium tanshinone IIA silate on ultra-microstructure of lung tissue in rats with limb ischemia-reperfusion injury |
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| Institution: | Li Zhijun, Meng Qingchun , Gao Shujie, Zhao Xiuhua, Zhu Ya, Kong Xiaoyan (1. Port Hospital of Hebei Port Group Co. , LTD, Qinhuangdao 066000, Hebei, China;2. Hebei United University, Tangs- han 063000, Hebei, China) |
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| Abstract: | Objective It is to explore the effect of sodium tanshinone ⅡA silate on ultra-microstructure of lung tissue in rats with limb ischemia-reperfusion injury .Methods 60 male SD rats were randomly divided into sham operation group （ group A）, simple ischemia-reperfusion group （group B） and sodium tanshinone ⅡA silate group （group C）.Limb ischemia-reper-fusion injury models of the rats were established by normal method .The histological and ultra-structure changes were observed under light microscope and electron microscope respectively .The levels of MDA , SOD and XOD in lung tissue of every group were determined by colorimetric method .Results Compared with that in group B , pulmonary vascular dilatation , inflammatory cell aggregation and tissue injury were obviously improved in group C , the activities of MDA , XOD were lower and that of SOD was higher in group C .Conclusion Sodium tanshinone IIA silate has an obvious protecting effect on lung tissue structure after limb ischemic-reperfusion . |
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| Keywords: | lung ischemia-reperfusion ultra-micro-structure sodium tanshinone IIA silate rat |
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