鼻咽癌调强适形放疗前后动态增强特征的研究

目的探讨鼻咽癌调强适形放疗前后MRI动态增强灌注成像的时间-信号变化特征。方法选择初诊未治疗鼻咽癌患者326例,于调强放疗前后行MRI动态增强扫描,分析病灶放疗前后的时间-信号强度变化的曲线特征。结果鼻咽癌放疗前动态增强曲线多呈速升-速降型或速升-平台型,放疗后动态增强曲线多呈缓慢上升型或缓升-平台型。结论调强适形放疗不仅可以缩小鼻咽癌的肿瘤体积,治疗其局部侵犯和淋巴结转移,同时可有效抑制肿瘤的血管生成,降低肿瘤活性。

Dynamic contrast-enhanced magnetic resonance imaging of nasopharyngeal carcinoma before and after intensity modulated radiotherapy

Objective To explore the features of time-signal curve of MRI dynamic enhancement of nasopharyngeal carcinoma before and after intensity modulated radiotherapy（IMRT）.Methods 326 patients with newly diagnosed nasopharyngeal carcinoma were included.Dynamical contrast enhanced MR imaging was performed before and after IMRT.The features of time-signal curve of lesions before and after intensity modulated radiotherapy were analyzed.Results The typical curve before IMRT was a rapidly ascending-rapidly descending one or a rapidly ascending-platform one.That of post-treatment was of slowly ascending or slowly ascending-platform.Conclusion Treatment with IMRT can not only shrink the size of tumor and treat the local invasion or lymph nodes metastasis,but also inhibit the angiogenesis in nasopharyngeal carcinoma.