纳洛酮联合依达拉奉治疗急性重型颅脑损伤的疗效观察

目的探讨纳洛酮联合依达拉奉治疗急性重型颅脑损伤的疗效。方法将168例急性重型颅脑损伤的患者随机分为两组,纳洛酮联合依达拉奉治疗组86例,在常规治疗的基础上纳洛酮3 mg加至生理盐水250 ml中静脉滴注,1次/d,连用14 d,同时加用依达拉奉30mg用生理盐水100 ml静脉滴注,1次/d,连用14 d。对照组82例,给予常规治疗,记录两组患者治疗前及治疗后14 d的脑水肿程度及格拉斯哥昏迷评分（GCS）。结果两组患者治疗前后脑水肿程度及GCS评分间差异均有统计学意义（P〈0.05）。结论纳洛酮联合依达拉奉治疗急性重型颅脑损伤的患者较常规治疗方法,疗效更好。

Efficacy observation on Naloxone combined with Edaravone in treatment of acute severe brain injury

Objective To analyze the effect of Naloxone combined with Edaravone in treatment of acute severe brain injury. Methods The 168 patients with acute severe brain injury were randomly divided into two groups.On the basis of conventional therapy,86 cases in Naloxone combined with Edaravone treatment group were given Naloxone 3mg in 250ml of normal saline by intravenous infusion 1/d for 14d continuously and Edaravone 30mg was added to 100ml of normal saline by intravenous infusion 1/d for 14d continuously.82 patients in control group were given conventional treatment.The level of brain edema in patients and Glasgow coma scale（GCS） were recorded before and 14d after treatment. Results The difference of the level of brain edema and GCS score between two groups before and after treatment had statistical significance（P0.05）. Conclusion Compare with conventional treatment methods,Naloxone combined with Edaravone has better efficacy for acute severe brain injury