精神分裂症患者Ig/C3双特异性循环免疫复合物与体液免疫的相关性研究

目的系统研究精神分裂症体液免疫各项目之间的相关性,探讨其免疫学意义。方法采用直线相关分析法系统研究了患者及对照组IgG/C3-TCIC（双特异性循环免疫复合物）、IgA/C3-TCIC、IgM/C3-TCIC水平与血清IgG、IgA、IgM及C3含量的相关性。结果健康人IgG/C3-TCIC、IgA/C3-TCIC、IgM/C3-TCIC水平与血清IgG、IgA、IgM及C3含量呈强弱不同的正相关;精神分裂症患者只显示IgG/C3-TCIC水平与血清IgG、C3呈负相关,其余均不相关。结论健康人Ig/C3-TCIC水平主要取决于血清总的IgG、IgA、IgM及补体C3的含量,而精神分裂症患者Ig/C3-TCIC水平的升降基本与血清免疫球蛋白（Ig）变化无关。Ig/C3-TCIC可作为观察患者免疫功能状态的独立指标。

Research on the correlation between Ig/C_3 two-component-determined circulating immune complexes in patients with schizophrenia and humoral immunity

Objective To investigate the correlation between Ig/C3 twocomponent-determined circulating immune complexes（TCIC） and humoral immunity systematically,and it＇s immunological significance. Methods We used linear correlation analysis to determine the correlation between the levels of Igs/C3（including IgG/C3,IgA/C3 and IgM/C3） TCIC and the levels of serum immunoglobulins（Igs,including IgG,IgA,and IgM） and C3,respectively in schizophrenic and control group. Results It shows positive correlation between the levels of IgG/C3-TCIC,IgA/C3-TCIC and IgM/C3-TCIC and the levels of serum IgG,IgA,and IgM and C3 in the healthy,to varying degrees;while it shows negative correlation or no correlation between levels of IgG/C3-TCIC and levels of serum IgG and C3 in the patient with schizophrenia. Conclusion The level of Ig/C3 TCIC in healthy people is determined by the total serum IgG,IgA,and IgM and C3,while the schizophrenic＇s Ig/C3-TCIC is not correlated with the serum immunoglobulin（Ig） in the gross,and so,Ig/C3-TCIC can be used as an independent indicator for patients＇ immune state.