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乙型肝炎血清前S1抗原与HBV-DNA和HBeAg相关性分析
引用本文:邓芝云,量菊子,朱发仁,张方信.乙型肝炎血清前S1抗原与HBV-DNA和HBeAg相关性分析[J].解放军医学高等专科学校学报,2011(6):1193-1194.
作者姓名:邓芝云  量菊子  朱发仁  张方信
作者单位:解放军兰州军区兰州总医院检验科,甘肃兰州730050
摘    要:目的探讨乙型肝炎血清前S1抗原(PreS1Ag)临床应用的价值。方法对365例乙型肝炎患者血清,采用酶联免疫吸附试验(ELISA)检测HBV血清标志物和PreS1Ag,用荧光定量聚合酶链反应(FQ-PCR)方法检测HBV-DNA。结果 HBV-DNA和PreS1Ag的阳性率在110例HBV大三阳中,分别为86.4%和89.1%;在66例HBV小三阳中,分别为36.4%和40.9%;在37例HBsAg、HBcAb中,分别为32.4%和41.7%;在39例HBeAg、HBcAb阳性中,分别为15.4%和15.4%;在113例HBsAb阳性中,分别为5.3%和8.0%。HBeAg、PreS1Ag阳性率随不同载量HBV-DNA升高而增高,但PreS1Ag比HBeAg增高更明显(P〈0.05)。结论 PreS1Ag和HBV-DNA一样都是乙型肝炎病毒复制的敏感指标,虽然PreS1Ag和HBeAg都随HBV-DNA载量增加而升高,但PreS1Ag较HBeAg更能敏感,因此PreS1Ag具有重要的临床应用价值。

关 键 词:乙型病毒性肝炎  HBV标志物  HBV-DNA  前S1抗原

The study on the relativity among HBeAg, HBV-DNA and PreSl-antigen
Deng Zhi-yun,Dong Ju-zi,Zhu Fa-ren,Zhang Fang-xin.The study on the relativity among HBeAg, HBV-DNA and PreSl-antigen[J].Clinical Journal of Medical Officer,2011(6):1193-1194.
Authors:Deng Zhi-yun  Dong Ju-zi  Zhu Fa-ren  Zhang Fang-xin
Institution:( Department of Clinical Laboratory, General Hospital of Lanzhou Command, PLA, Lanzhou Gansu 730050, China)
Abstract:Objective To study the clinical application value of Presl-antigen. Methods The HBV markers and Presl-antigen were detected by enzyme linked immunosorbent assay (ELISA) and the HBV-DNA was detected by fluorescent quantitation poly-merase chain reaction (FQ-PCR) in 365 patients with hepatitis B. Results The positive rates of the HBV-DNA and Presl were 86.4% and 89. 1% in 110 patients of HBsAg+, HBeAg + and HBcAb + ; 36.4% and 40.9% in66 patients of HBsAg + ,HBeAb + and HBcAb + ;32.4% and 41.7% in 37 patients of HBsAg + and HBcAb + ; 15.4% and 15.4% in 39 patients of HeAg + and HBcAb + ;5.3% and 8.0% in 113 patients of HBsAb +. The positive rates of HBeAg and PreS1Ag increased with increasing HB~-DNA, PreS1Ag was increased significantly compared with HBeAg ( P 〈 0.05). Conclusion Presl and HBV-DNA are the sensitive index for HBV replication, though PreS1Ag and HBeAg Presl increased with increasing HBV-DNA, PreS1Ag is more sensitive than HBeAg, and it is valuable in clinical application.
Keywords:hepatitis B  HBV markers  HBV-DNA  PreSl-antigen
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