Neurobehavioral effects of amantadine after pediatric traumatic brain injury: a preliminary report |
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Authors: | Beers Sue R Skold Anna Dixon Clifton Edward Adelson Philip David |
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Affiliation: | Traumatic Brain Injury Program, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA. beerssr@upmc.edu |
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Abstract: | OBJECTIVE: To investigate the safety and efficacy of a dopamine agonist, amantadine hydrochloride (AMH), in the treatment of neurobehavioral sequelae of pediatric TBI. PROCEDURES: Age- and severity-matched traumatic brain injury groups, randomized to AMH (n = 17) or usual care (n = 10), completed behavior scales and neuropsychological tests. Effect sizes measured the treatment effect within subjects and between groups. Side effects were tracked over the 12-week study course. RESULTS: Behavior improved in the AMH group, but only those 2 years or fewer postinjury showed a treatment effect on cognitive tests. CONCLUSIONS: After traumatic brain injury, a 12-week course of AMH was safe and, according to parent report, improved behavior. AMH may have the potential to improve cognition in more recently injured children. |
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