左氧氟沙星序贯疗法治疗幽门螺杆菌感染引起的消化性溃疡的临床体会

目的：探讨临床应用左氧氟沙星序贯疗法的疗效及安全性。方法：回顾性分析本院2010年3月～2011年3月收治的89例消化性溃疡患者,将其分为治疗组51例和对照组38例,治疗组采用10d序贯疗法,在前5d的诱导期中,使用质子泵抑制剂奥美拉唑20mg和阿莫西林1000mg,每日2次口服。后5d采用奥美拉唑20mg和左氧氟沙星200mg以及呋喃唑酮100mg,每日2次口服。在序贯疗法结束时,再给予奥美拉唑20mg每日2次口服7d。对照组采用传统三联疗法,奥美拉唑20mg和阿莫西林1000mg以及甲硝唑400mg,均每日2次。连续口服14d。结果：两组患者治疗4周后的快速尿素酶试验结果差异有统计学意义（P〈0.05）,溃疡愈合率差异亦有统计学意义（P〈0.05）。治疗组的治疗方案较对照组疗效高且不良反应低。结论：采用左氧氟沙星治疗幽门螺杆菌感染引起的消化性溃疡的序贯疗法,具有疗效高、不良反应少的优点。

Clinical experience of levofloxacin sequential therapy in treatment of Helicobacter Pylori associated peptic ulcer

Objective： To evaluate the clinical efficacy and safety of levofloxacin sequential therapy in the treatment of Helicobacter pylori associated peptic ulcer. Methods： Eighty nine patients from March 2010 to March 2011 were slected and were divided into treatment group and control group. The treatment group were treated with 10 days sequential therapy, in the first five days of induction period, used proton pump inhibitors omeprazole 20 mg and amoxicillin 1 000 rag, oral for 2 times a day. The next 5 days used omeprazole 20 mg and 200 mg of levofloxacin and furazolidone 100 mg, oral for 2 times a day. Sequential therapy in the end, and then gave omeprazole 20 mg, oral twice daily for 7 days. Control group were used traditional triple therapy, omeprazole 20 mg and amoxicillin 1 000 mg and metronidazole 400 mg, all twice daily. Continuous oral of 14 days. Results： Two groups of patients after four weeks of rapid urease test result was statistically significantly different （P〈0.05）, ulcer healing rate also had statistically significant difference （P〈0.05）. There was higher ef- ficacy and lower adverse reactions of the treatment group than that of the control group. Conclusion： The advantages of levofloxacin sequential therapy in treatment of Helicobacter Pylori associated peptic ulcer has high efficacy and fewer ad- verse reactions.