NT-proBNP在慢性心力衰竭中的诊断价值

目的：探讨氨基末端脑钠肽前体（NT-proBNP）的水平变化在诊断慢性心力衰竭患者中的价值和意义。方法：采用氨基末端脑钠肽前体（NT-proBNP）试剂盒检测35例慢性心力衰竭患者（观察组一）和15例无症状性心力衰竭患者（观察组二）的NT-proBNP水平,并与15例健康成人（对照组）作对照。结果：心力衰竭患者、无症状性心力衰竭患者和健康体检者的NT-proBNP水平分别为（850.5±325.0）、（434.3±135.7）和（112.3±29.4）ng/L,组间两两比较差异均有统计学意义（P均〈0.01）;3组的NT-proBNP水平的95%可信区间分别为767.9～925.6、368.0～520.4和93.1～119.8ng/L;NT-proBNP水平对心力衰竭的诊断界值为120ng/L时,诊断敏感性和特异性分别为100.0%和87.6%;心功能Ⅰ、Ⅱ、Ⅲ和Ⅳ级时NT-proBNP水平分别为（429.8±129.6）、（638.7±237.5）、（878.9±320.8）和（1033.7±545.9）ng/L,各级间差异有统计学意义（P均〈0.01）;NT-proBNP水平与心功能分级呈正相关（r=0.823,P〈0.01）,与原发病不相关（P〉0.05）。结论：NT-proBNP水平对慢性心力衰竭患者诊断具有重要临床价值。

Brain natriuretic peptide in the diagnosis of chronic heart failure

Objective： To investigate brain natriuretic peptide （NT-proBNP） levels value and significance in diagnosis of patients with chronic heart failure. Methods： Took quantitative immunofluorescence assay detect 35 cases chronic heart failure patients （study group 1） and 15 asymptomatic heart failure patients （study group 2） brain natriuretic peptide levels, and compared with 15 healthy adults （control group）. Results： The patients with heart failure, heart failure with healthy asymptomatic patients brain natriuretic peptide levels were （850.5±325.0）, （434.3±135.7） and （112.3±29.4） ng/L, the dif- ference between the two groups were statistically significant （P〈0.01）; three groups of brain natriuretic peptide levels in 95% confidence interval, respectively were 767.9-925.6, 368.0-520.4 and 93.1-119.8 ng/L; when brain natriuretic peptide levels for diagnosis of heart failure circles was 120 ng/L, the diagnostic sensitivity and specificity were 100% and 87.6%; cardiac function grade I, II grade, III and IV grade level of brain natriuretic peptide levels were （429.8±129.6） ng/L, （638.7±237.5）, （878.9±320.8） and （1 033.7±545.9） rig/L, there were significant difference between the various levels （P〈 0.01）; brain natriuretic peptide levels and cardiac function was positively correlated （r=0.823, P〈0.01）, with primary disease not related （P〉0.05）. Conclusion： Brain natriuretic peptide level in patients with chronic heart failure diagnosis has important clinical walue.