复方双密达莫缓释双层片释放度的测定 |
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引用本文: | 王丹.复方双密达莫缓释双层片释放度的测定[J].中国当代医药,2011,18(34):44-45. |
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作者姓名: | 王丹 |
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作者单位: | 漯河医专药学系,河南漯河,462002 |
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摘 要: | 目的:测定复方双嘧达莫缓释双层片的释放度,并与进口制剂的释放度做比较。方法:采用UV法测定复方双嘧达莫缓释片及其参比制剂的释放度及含量。结果:在选定的波长处,辅料及阿司匹林对测定无干扰,释放度平均回收率为98.11%,含量平均回收率为102.1%。结论:两种缓释片的体外释放相似,复方双嘧达莫缓释双层片是一个具有良好释放特性的口服缓释制剂,其进口制剂Aggrenox具有类似的释药行为。
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关 键 词: | 双嘧达莫 缓释 释放度 复方 |
Determination of drug release rate of the compound dipyridamole double-layer sustained-relesae tablets |
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Authors: | WANG Dan |
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Institution: | WANG Dan Department of Pharmacy,Luohe Medical College,Henan Province,Luohe 462300,China |
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Abstract: | Objective: To investigate release characteristics in vitro of compound dipyridamole double-layer sustained-relesae tablets and compared with imported formulations release. Methods: The rate of release and content of sustained-re- lease dipyridamole were determinated by UV. Results: In the selected wavelengths, auxiliary materials and aspirin to de- termine no interference, the recovery of release was 98.11%, the recovery of content was 102.1%. Conclusion: The sus- tained-relesae dipyridamole tablets is a preparation with good release characters and its release behavior is similar with Aggrenox. |
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Keywords: | Dipyridamole Sustained-relesae Release rate Compound |
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