胃肠道转流对合并糖尿病胃癌患者糖代谢的影响研究

目的：探讨胃肠道转流对合并糖尿病的胃癌患者糖代谢的影响。方法：选择68例合并2型糖尿病的胃癌患者作为研究对象,均接受肿瘤根治性切除及胃肠道转流手术,观察术后糖代谢变化及胰岛素第一分泌时相变化。结果：术后1个月FPG、2hPG水平下降,术后6个月及术后12个月接近正常,患者术后1周胰岛素分泌峰值提前,第一时相胰岛素净分泌量增加,术后6个月及12个月,胰岛素分泌峰值提前及第一时相胰岛素净分泌量增加更为明显。结论：胃肠道转流能够影响合并2型糖尿病胃癌患者的糖代谢,其可能同胰岛素分泌变化有关。

Effects of gastric-bowel bypass to glycometabolism on gastric cancer with 2 diabetic

Objective： To investigate the effect of gastric-bowel bypass to glycometabolism on patients with gastric cancer combined 2 diabetic （2DM）. Methods： 68 cases of patients with gastric cancer combined 2DM were selected as research object and taken gastric cancer radical excision and gastric -bowel bypass, observed the change of glycometabolism and first secretion pases of insulin after operation. Results： One month after operations, fasting plasma glucose （FPG）, and 2hPG was lower, the level of FPG and 2hPG were intimate to normal level in 6 and 12 month after operations, one week after op - erations, peak of insulin advanced and secretory volume of insulin in first secretion pases was increasing, along time lenthing, peak of insulin advanced and secretory volume of insulin was more apparente. Conclusion： Gastric-bowel bypass has effect in glycometabolism on patients with gastric cancer combined 2 diabetic, that maybe is result of change in insulin secretion.