气相色谱法测定乳酸左氧氟沙星中有机溶剂残留量

目的：建立乳酸左氧氟沙星中有机溶剂残留量的测定方法。方法：采用毛细管气相色谱法,色谱柱为HP-5毛细管柱（30m×0.32mm×0.25μm）,程序升温技术,用内标对比法分离测定甲磺酸左氧氟沙星的残留溶剂。结果：两种溶剂在各自对应的浓度范围内线性关系良好（r〉0.9996）,平均回收率分别为100.42%、100.24%,RSD分别为0.775%、0.778%,最低检测限为7.1、11.0ng。结论：该方法灵敏、准确、可靠,适用于本品有机溶剂残留量的检测。

Determination of residual organic solvents in levofloxacin lactate by gas chromatography

Objective： To establish a method for determination of residual solvent in levofloxacin lactate. Methods： Residual solvent in levofloxacin mesylate were determined by capillary gas chromatog raphy using a HP-5 capillary column （30 m × 0.32 mm×0.25 μm）, and a detector of FID, and a direct injection. Results： The 2 solvents showed good linear relationship within a certain concentration range （r0.999 6）. Residual solvents were well separated in the column with the respective mean recovery range of 100.42% and 100.24%. The respective repeatability （RSD） was 0.775% and 0.778%, and the respective detection limits was 7.1 ng and 11.0 ng. Conclusion： The method has been proved to be accurate and sensitive. It is quite suitable for content determination of organic solvents in levofloxacin lactate.