Association of Escherichiacoli O157:H7 with necrotizing enterocolitis in a full-term infant |
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| Authors: | Yigit S. Guner Ajay Malhotra Henri R. Ford James E. Stein Lisa K. Kelly |
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| Affiliation: | (1) Department of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA, USA;(2) Department of Surgery, University of California Davis Medical Center, Sacramento, CA, USA;(3) Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;(4) Department of Pediatrics, Keck School of Medicine, Center for Fetal and Newborn Medicine, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS #31, Los Angeles, CA 90027, USA |
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| Abstract: | Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC. |
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| Keywords: | Neonate NEC Mortality HUS Bacteria |
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