Early organ dysfunction course,cooling time and outcome in classic heatstroke

Purpose  To describe the course of early organ dysfunction in a cohort of patients admitted in ICU suffering classic heatstroke. Methods  Prospective observational single-centre cohort study with a 1-year follow-up. Interventions  None. Measurements and main results  Clinical and biological data of 22 patients were analysed. Median body temperature on admission was 41.1°C. Respiratory, circulatory, haematological, hepatic and renal function all deteriorated within the first 24 h of admission. ICU-mortality was 63.6%. Cooling time, serum lactate, serum cardiac troponin I and creatinine were significantly higher in non-survivors. Early ICU-mortality (within 7 days of ICU stay) was due to multiple organ failure. Late ICU-mortality was due to neurological disability. Conclusions  Classic heat stroke may demonstrate a rapidly worsening organ dysfunction course leading to death even though cooling procedures and intensive care management are promptly started. Presented in part at the 17th Annual Congress of the European Society of Intensive Care Medicine, Berlin, 2004 (Intensive Care Med 30: S776).