Novel open-chain cytochalsins from the marine-derived fungus Spicaria elegans |
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Authors: | Liu Rui Lin Zhenjian Zhu Tianjiao Fang Yuchun Gu Qianqun Zhu Weiming |
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Affiliation: | Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, People's Republic of China. |
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Abstract: | Six novel open-chain cytochalasins (1-6) and one known [12]-cytochalasin (7) have been isolated from the fermentation broth of a marine-derived fungus, Spicaria elegans. Cytochalasins Z10-Z15 (1-6) are the first reported cytochalasins that contain an open chain to date. The structures of these new compounds were elucidated by spectroscopic methods. The cytotoxic effects on P388, A-549, HL-60, and BEL-7402 cell lines of all compounds were evaluated by the MTT method. |
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