| Angiotensin Ⅰ-converting enzyme gene poly morphism in Chinese patientswith obstructive sleep apnea syndrome |
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| 引用本文： | 肖毅,黄席珍,邱长春,朱席琳,刘怡文.Angiotensin Ⅰ-converting enzyme gene poly morphism in Chinese patientswith obstructive sleep apnea syndrome[J].中华医学杂志(英文版),1999,112(8). |
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| 作者姓名： | 肖毅 黄席珍 邱长春 朱席琳 刘怡文 |
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| 作者单位： | XIAO Yi 肖 毅，HUANG Xizhen 黄席珍，QIU Changchun 邱长春，ZHU Xilin 朱席琳 and LIU Yiwen 刘怡文 |
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| 摘 要： | ＴｈｅｍａｊｏｒｆｕｎｃｔｉｏｎｓｏｆａｎｇｉｏｔｅｎｓｉｎⅠｃｏｎｖｅｒｔｉｎｇｅｎｚｙｍｅ（ＡＣＥ）ａｒｅｔｈｅｃｏｎｖｅｒｓｉｏｎｏｆａｎｇｉｏｔｅｎｓｉｎＩｔｏｔｈｅｖａｓｏａｃｔｉｖｅ，ａｎｔｉｎａｔｒｉｕｒｅｔｉｃｏｃｔａｐｅｐｔｉｄｅａｎｇｉｏｔｅｎｓｉｎＩＩ，ａｎｄｔｈｅｉｎａｃｔｉｖａｔｉｏｎｏｆｋｉｎｉｎｓ．ＡＣＥｉｓｅｎｃｏｄｅｄｂｙａ２１ｋｂ，２６ｅｘｏｎｇｅｎｅｌｏｃａｔｅｄｏｎｃｈｒｏｍｏｓｏｍｅ１７ａｔｑ２３．ＡｐｏｌｙｍｏｒｐｈｉｓｍｏｆｔｈｅＡＣＥｇｅｎｅｉ…
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| 关 键 词： | angiotensin Ⅰ converting enzyme · gene polymorphism · obstructive sleep apnea syndrome |
Angiotensin Ⅰ-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome |
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| XIAO Yi,HUANG Xizhen,QIU Changchun.Angiotensin Ⅰ-converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome[J].Chinese Medical Journal,1999,112(8). |
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| Authors: | XIAO Yi HUANG Xizhen QIU Changchun |
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| Abstract: | Objective To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS) patients and the control subjects.Methods Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers flanked the polymorphic region in intro 16 of the ACE gene. Results OSAS patients had significantly higher frequencies of I/I genotype and insertion allele of the ACE gene as compared with the control subjects in Chinese population. The OSAS patients with I/I genotype had significantly longer apnea time, lower minimum SaO2 and greater AHI than the OSAS patients with I/D genotype. Conclusion These results indicate that the I/I genotype and I allele are a risk factor for OSAS in Chinese. |
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