子宫颈癌中环氧化酶-2与Ki-67增生指数、bax、微血管密度以及CD44v6关系的研究

 目的 探讨子宫颈癌中环氧化酶-2（COX-2）与细胞核抗原Ki-67增生指数、促凋亡基因产物bax蛋白、微血管密度（MVD）以及CD44v6之间的关系，从而探讨COX-2参与子宫颈癌发生、发展的可能机制。方法 采用组织芯片技术结合免疫组织化学PV法分别检测子宫颈癌中COX-2，Ki-67，bax，MVD（用CD34标记）和CD44v6的表达，并分析它们之间的关系。结果 子宫颈癌中COX-2的表达分别与Ki-67标记指数（r = 0.199，P = 0.001）、MVD呈显著正相关（r = 0.316，P＜0.001），与CD44v6呈正相关（r = 0.150，P = 0.039）；而COX-2的表达与bax的表达无直线相关关系（r = 0.064，P = 0.344）。结论 COX-2参与子宫颈癌的机制可能与促进肿瘤血管形成、促进细胞增生及细胞黏附有关，与bax的表达无直接关系。

The relationship between COX-2 and Ki-67 proliferation index, bax, microvascular density and CD44v6 in cervical carcinoma

Objective To investigate the relationship between COX-2 and Ki-67 proliferation index, bax, microvascular density(MVD)and CD44v6 respectively. Methods The expression of COX-2,Ki-67, bax, MVD (labelled by CD34) and CD44v6 were examined by immunohistochemistry PV method and tissue chip method in 101 cases of cervical carcinomas epithelium. Results The expression of COX-2 in cervical carcinomas has positive correlation with Ki-67, MVD and CD44v6, but has no correlation with bax. Conclusion The probable mechanisms are related with neovascularization, cell proliferation and cell adherence, but not related with the expression of bax.