| 短期鼻用皮质类固醇激素对儿童骨密度的影响 |
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| 引用本文： | 李哲,孟大为,马云鹏,赵方,吴玉杰,暴继敏. 短期鼻用皮质类固醇激素对儿童骨密度的影响[J]. 中国耳鼻咽喉头颈外科, 2009, 16(1): 43-45 |
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| 作者姓名： | 李哲 孟大为 马云鹏 赵方 吴玉杰 暴继敏 |
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| 作者单位： | 辽宁省友谊医院耳鼻咽喉科,辽宁,沈阳,110015:;辽宁省金秋医院耳鼻咽喉科,辽宁,沈阳,110016;辽宁省金秋医院骨外科,辽宁,沈阳,110016;辽宁省金秋医院骨密度室,辽宁,沈阳,110016 |
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| 基金项目： | 基金项目：“十五”国家科技攻关项目（2004BA720A17）,辽宁省自然基金项目（20042114）和辽宁省科技计划项目（2004225003-19）联合资助 |
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| 摘 要： | 目的探讨短期鼻用皮质类固醇激素对儿童骨密度的影响。方法对28例5～8岁慢性鼻及鼻窦炎合并腺样体肥大的患儿，腺样体切除术后采用糠酸莫米松鼻喷雾剂，每日展起给予100旧喷鼻，共5周，用双能X线骨密度仪监测治疗前和治疗后1年骨密度及Z评分。结果对治疗前和治疗后1年结果行统计分析，差异均无显著（P〉O．05）。结论标准治疗剂量的鼻用皮质类固醇激素对儿童骨密度无明显影响。
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| 关 键 词： | 肾上腺皮质激素类 投药 鼻内 骨密度 儿童 |
Effect of short term using of intranasal steroids spray on bone mineral density in the children |
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| Affiliation: | LI Zhe, MENG Dawei, MA Yunpeng, ZHAO Fang, WU Yujie, BAO Jimin ( 1 Department of Otolaryngology, Friendship Hospital of Liaoning Province, Shenyang, Liaoning, 110015, China; 2 Department of Otolaryngology, 3 Department of Orthopaedic Surgery, 4 Bone Density Room, Jinqiu Hospital of Liaoning Province, Shenyang, Liaoning, 110016, China) |
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| Abstract: | OBJECTIVE To investigate the effect of short term Using of intranasal steroids spray on bone mineral density in children. METHODS A one-year randomized study was conducted on the effect of short term using of intranasal steroids spray on bone mineral density in 28 children patient with chronic rhinitis- rhinosinusitis and enlarged adenoids. They all received adenoidectomy. The age of the 28 children ranged from 5 to 8 years old. After adenoidectomy, they used nasal spray Nasonex, 100 pg per day, for 5 weeks. BMD and Z-score was measured by dual energy X-ray absorptiometry at the beginning of treatment and 1 year after treatment. RESULTS There was no significant difference in bone mineral density before and after treatment （P〉0.05） . CONCLUSION Short term using of intranasal steroids spray in children didn＇t lead to osteoporosis if standard dose was given. |
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| Keywords: | Adrenal Cortex Hormones Administration, Intranasal Bone Density Child |
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