Ph染色体阳性急性髓系白血病细胞免疫表型及临床特征研究

目的　探讨 Ph染色体阳性急性髓系白血病 ( AML)患者细胞免疫表型及临床特征。方法　对 7例初诊为 Ph染色体阳性 AML 患者进行细胞形态学、细胞遗传学及细胞免疫表型检测 ,结合患者白细胞数、感染情况及临床治疗的疗效和生存期进行综合分析。结果　 Ph染色体阳性 AML7例 ,占同期 AML 患者的 3 .5 % ,细胞免疫表型伴淋系表达率高 (占 4 2 .9% ) ,CD3 4表达均阳性。完全缓解率为 4 2 .9% ,平均生存期 11个月。结论　 Ph染色体阳性 AML在细胞免疫表型、形态学及临床特征方面有其特殊性 ,疗效差 ,生存期短

The cytoimmunological phenotype and clinical features of Philadelphia chromosome (Ph)-positive acute myelogenous leukemia (AML)

Objective To investigate the cytoimmunological phenotype and clinical features of Philadelphia chromosome (Ph) positive acute myelogenous leukemia (AML). Methods Cytomorphological,cytogenetical and cytoimmunological phenotype tests were conducted on 7 patients with clinically diagnosed Ph positive AML,in conjunction with their white blood cell count,status of infection,treatment efficacy and survival duration. Results The diagnosis of Ph positive AML cases were confirmed,which comprised 3.5% of all AML cased diagnosed in the same period.Cytoimmunological phenotype with lympho expression rate was high (42.8%).All cases showed positive CD34 expression.FAB classification showed M 1,M 2 and M 4 dominant.Complete remission rate was 42.8%,and average survival duration was 11 months. Conclusion Philadelphia chromosome (Ph) positive AML is found to exhibit special features in cytoimmunological expression and cytomorpholgoy,and poor treatment efficacy and short survival time.